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KMID : 1177320210240020060
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Korean Journal of Schizophrenia Research
2021 Volume.24 No. 2 p.60 ~ p.67
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Association of the First Antipsychotic Treatment Duration With the Re-Initiation of Treatment in Schizophrenia: A National Health Insurance Data-Based Study
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Song Min-Ho
Lee Jung-Sun
Kim Ha-Rin
Ahn Soo-Jin
Choi Young-Jae
Jo Young-Tak
Joo Sung-Woo
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Abstract
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Objectives: The optimal duration of maintenance treatment for patients with first-episode schizophrenia (FES) remains unclear. We examined the first antipsychotic treatment duration and its association with re-initiation of treatment using a nationwide claim database.
Methods: Data from the Health Insurance Review and Assessment Service database in South Korea for 2007?2016 were used. Linear regression analysis and Cox proportional hazard models were used to evaluate the associations between the duration of the first antipsychotic treatment, time to re-initiation of treatment, and occurrence of treatment re-initiation.
Results: Of 30,143 patients with FES, 80.4% (n=24,231) received <2 years of the first antipsychotic treatment. In patients who discontinued treatment (n=23,030), the rate of treatment re-initiation was 74.2% (n=17,086). As the duration of the first antipsychotic treatment increased, the time to re-initiation of treatment decreased (β=-0.146, p<0.001); however, the rate of treatment reinitiation was relatively constant (hazard ratio=1.001, p<0.001).
Conclusion: Long-term antipsychotic treatment was not significantly associated with the rate of treatment re-initiation but showed a negative association with the time to re-initiation of treatment. Further research is needed to better understand the optimal treatment duration for FES.
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KEYWORD
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Antipsychotic treatment, Re-initiation of treatment, Schizophrenia
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